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Requisition ID:  7689

Scientist - Assay Development & HTS - Center for Alzheimer's Disease Drug Discovery

Job Summary

*Updated, August 20, 2020*: This position is actively recruiting and accepting applications.

The Assay Development & HTS Scientist for the Alzheimer’s Disease Drug Discovery Center (ADDD Center) within the Purdue University Institute for Drug Discovery will be responsible for performing high-throughput screening and testing of molecules.  This position will develop in vitro and cell-based assays for novel Alzheimer’s Disease targets in order to perform low-, medium-, and high-throughput screening.  This will also require the generation of recombinantly expressed protein through the most appropriate expression systems (e.g. bacterial, yeast, insect, etc.) and purification of these proteins.  This position also will perform secondary and follow-up testing on hits, structure-activity-relationship (SAR) sets, and various compound series synthesized by medicinal chemists using biochemical and mammalian cell culture.  Additionally, the Assay Development & HTS Scientist will meet regularly with other Center research staff to identify the most promising Alzheimer’s Disease targets, develop strategies for assays & screening in order to identify new small molecule modulators of these targets, and share generated in vitro test data to help guide medicinal chemistry efforts to refine chemical series in an effort to develop lead compound series and eventual clinical candidates.
This position will be supported for duration of the five-year contract of the ADDD Center.
Required: 

  • Master’s Degree in Biochemistry, Biology, Chemical Biology or closely related field
  • Two (2) years of industry experience
  •  Design of vectors and performing recombinant protein expression in bacterial, yeast and/or insect cells
  • Experience with purifying recombinantly expressed proteins
  • Development of assays to measure binding, activity, and/or cellular phenotypes for low-, medium-, and high-throughput screening
  • Experience working with automated/robotic equipment (e.g. liquid handlers, plate readers, etc.)
  • Ability to maintain and test mammalian cell cultures in a sterile BSL2 environment
  • Knowledge of general biology, molecular biology, and chemistry techniques
  • Ability to carry-out laboratory experiments in an independent manner with little supervision 
  • Basic skills in communication, word processing, data entry, and data analysis
  • Familiarity with Microsoft office software (e.g. Word, Excel, Powerpoint, etc.) 

Preferred:

  • Ph.D. Degree

Additional Information: 

  • This position posting represents two vacancies
  • Purdue will not sponsor employment authorization for this position
  • A background check will be required for employment in this position
  • FLSA: Exempt (Not Eligible For Overtime
  • Retirement Eligibility: Defined Contribution Waiting Period
  • Purdue University is an EOE/AA employer. All individuals, including minorities, women, individuals with disabilities, and veterans are encouraged to apply